Wuhan Nutra Biotechnology Co., Ltd.

Wuhan Nutra Biotechnology Co., Ltd.

SARMS & Sports Nutrition & Human Growth Hormone
 search
new sarms gw0742
Product Name:
new sarms gw0742
No. :
317318-84-6
:
:

Product Description:

 

GW0742/GW 610742 Cas No. 317318-84-6

GW0742 is the transcription factor peroxisome proliferator-activated receptor δ (PPARδ) is a member of the superfamily of nuclear hormone receptors and is implicated both in lipid metabolism and in the regulation of genes with potential roles in neurotoxicity. GW 0742 is a selective PPARδ agonist (EC50 = 1.1 nM) that exhibits 1,000-fold selectivity over the other human PPAR subtypes. GW 0742 exhibits time-dependent neuroprotection in low KCl-induced apoptosis in cerebellar granule neuronal cultures. Despite the neuroprotective properties observed, prolonged (48h) incubation with GW 0742 produced significant inherent toxicity. This cell death was determined to be apoptotic as identified with the TUNEL assay