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PRL-8-53
Product Description:
Product Name: PRL-8-53
Synonyms: PRL-8053;PRL-8-53;Methyl 3-(2-(benzyl(Methyl)aMino)ethyl)benzoate hydrochloride;3-(2-Benzyl(methyl)aminoethyl)benzoic acid methyl ester hydrochloride;m-[2-(Benzylmethylamino)ethyl]benzoic acid methyl ester hydrochloride;Benzoic acid, 3-(2-(Methyl(phenylMethyl)aMino)ethyl)-, Methyl ester, hydrochloride
CAS: 51352-87-5
MF: C18H22ClNO2
MW: 319.82578
PRL-8-53 Overview
PRL-8-53 is a nootropic research compound first synthesized in the 1970’s by Dr Nikolaus Hansl while working at Creighton University. The compound takes its name from creator’s company Pacific Research Labs who were also the (now expired) patent holders. Very little research on this compound is available online. What is available appears to have been conducted by the old patent holder.
The single study involving humans showed PRL-8-53 improved word recollection scores both 24 and 96 hours after initial memorization. Given the low amount of evidence available for this nootropic, we thought it relevant to reference a journal article in which the creator discusses the compound and numerous other human trials it was used in.
Benefits of PRL-8-53
Memory
The single published study for PRL-8-53 shows a slight improvement of word acquisition during a memorization task. Participants were given 5mg of PRL-8-53 2 hours prior to testing and then were then asked to listen to a recording of 12 words in a particular sequence and recite them at future time points (shortly after testing, a day after and 4 days after). Minor benefits were found for immediate acquisition, but an over 80% improvement was noted for people tested later on who had initially scored poorly for the test (6/12 words correctly or below) [1].
Unpublished (Possible) Benefits – Geometric Pattern Exercise
Interestingly, the compound creator also discusses other trials which appear to be unavailable or unpublished. In a Journal published in 1978, Dr Hansl mentions that PRL-8-53 statistically improved scores in a geometric pattern cognitive exercise. Participants were shown a series of geometric patterns and ask to draw them from memory, a statistical improvement was noted.
Mental Arithmetic Exercise
In the same article, Dr Hansl mentions a number based cognitive exercise where participants had to subtract 7, add 1, subtract 7, add 2 and so on until a “goal” number was reached. Shorter times to the “goal” number were noted in the PRL-8-53 group.
Verbal Fluency Test
Dr Hansl discusses a test where subjects were asked to form words from a series of letters and dots. For example “U.R.” had to be turned into any word by adding letters at the start and end of the word, while replacing the dots with a letter. “U.R.” could be “current” for example. A statistically significant improvement was found in participants who had taken the drug.
Dosing PRL-8-53
The single published human study used 5mg of PRL-8-53 and found it enhanced recall on a word-remembering test. The patent for the compound mentions an oral dose of 0.01mg/kg per dose, taken 3 times per day.
Synonyms: PRL-8053;PRL-8-53;Methyl 3-(2-(benzyl(Methyl)aMino)ethyl)benzoate hydrochloride;3-(2-Benzyl(methyl)aminoethyl)benzoic acid methyl ester hydrochloride;m-[2-(Benzylmethylamino)ethyl]benzoic acid methyl ester hydrochloride;Benzoic acid, 3-(2-(Methyl(phenylMethyl)aMino)ethyl)-, Methyl ester, hydrochloride
CAS: 51352-87-5
MF: C18H22ClNO2
MW: 319.82578
PRL-8-53 Overview
PRL-8-53 is a nootropic research compound first synthesized in the 1970’s by Dr Nikolaus Hansl while working at Creighton University. The compound takes its name from creator’s company Pacific Research Labs who were also the (now expired) patent holders. Very little research on this compound is available online. What is available appears to have been conducted by the old patent holder.
The single study involving humans showed PRL-8-53 improved word recollection scores both 24 and 96 hours after initial memorization. Given the low amount of evidence available for this nootropic, we thought it relevant to reference a journal article in which the creator discusses the compound and numerous other human trials it was used in.
Benefits of PRL-8-53
Memory
The single published study for PRL-8-53 shows a slight improvement of word acquisition during a memorization task. Participants were given 5mg of PRL-8-53 2 hours prior to testing and then were then asked to listen to a recording of 12 words in a particular sequence and recite them at future time points (shortly after testing, a day after and 4 days after). Minor benefits were found for immediate acquisition, but an over 80% improvement was noted for people tested later on who had initially scored poorly for the test (6/12 words correctly or below) [1].
Unpublished (Possible) Benefits – Geometric Pattern Exercise
Interestingly, the compound creator also discusses other trials which appear to be unavailable or unpublished. In a Journal published in 1978, Dr Hansl mentions that PRL-8-53 statistically improved scores in a geometric pattern cognitive exercise. Participants were shown a series of geometric patterns and ask to draw them from memory, a statistical improvement was noted.
Mental Arithmetic Exercise
In the same article, Dr Hansl mentions a number based cognitive exercise where participants had to subtract 7, add 1, subtract 7, add 2 and so on until a “goal” number was reached. Shorter times to the “goal” number were noted in the PRL-8-53 group.
Verbal Fluency Test
Dr Hansl discusses a test where subjects were asked to form words from a series of letters and dots. For example “U.R.” had to be turned into any word by adding letters at the start and end of the word, while replacing the dots with a letter. “U.R.” could be “current” for example. A statistically significant improvement was found in participants who had taken the drug.
Dosing PRL-8-53
The single published human study used 5mg of PRL-8-53 and found it enhanced recall on a word-remembering test. The patent for the compound mentions an oral dose of 0.01mg/kg per dose, taken 3 times per day.
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