 |
Wuhan Nutra Biotechnology Co., Ltd.ISRIB ,Cosmetic Peptide, Tideglusib ,Way316606,Nootropics |
    
   
|
|||
Contact Us
E-mail: catherine@nutrabiotechchem.com
Semax
Product Description:
Product Name: ACTH (4-7), Pro-Gly-Pro-
Synonyms: ACTH (4-7), Pro-Gly-Pro-;ACTH (4-7), Pro-Gly-Pro trifluoroacetate salt;L-Methionyl-L-a-glutamyl-L-histidyl-L-phenylalanyl-L-prolylglycyl-L-proline trifluoroacetate salt;Met-Glu-His-Phe-Pro-Gly-Pro;Semax
CAS: 80714-61-0
MF: C37H51N9O10S
MW: 813.929
Semax review
Semax is a heptapeptide developed by the Institute of Molecular Genetics, Russian Academy Of Science (IMG RAS)[1]. Semax was likely first developed in the 1980’s to early 1990’s and received authorization for marketing in 1994.[1]. In Russia, Semax is used to treat stroke, brain damage following ischemia, optic nerve disease and as a treatment for various cognitive disorders[2]. Additionally Semax has been shown in one human study to directly enhance cognitive function and favorably alter EEG bands
Benefits of Semax
Cognitive Enhancement
A 2 day study of Russian power plant workers tested the efficacy of Semax with a number memorization task.[4] In total the test lasted around 15 minutes and one was performed at the beginning and end of the workers’ shifts on days 1 and 2 respectively.
A dose of 1mg was given intranasally on day one around 1 hour prior to testing and on day two shortly after the morning’s tests. A placebo group was also requested to perform the same task
Semax dramatically decreased the number of incorrect responses on days one and two while the placebo group’s error rate actually increased (see above). Semax also attenuated a decrease in correct performance scores compared to placebo.
Mood
Animal studies reveal Semax is a potential mood enhancer and anxiety reducing compound. A study of in rats revealed Semax to be capable of attenuating CCK-4 induced stress and depression, while not affecting rats administered placebo.
Migraines
A study conducted in 1995 sought to test the analgesic activity of Semax and if it could be suitable for headache and migrane relief. The study featured 3 groups of patients; group 1 was 12 individuals suffering from migraines, group 2 included 16 patients suffering with trigeminal neuralgia while group 3 included 9 patients suffering with dental plexalgia
Potentiation Of Stimulants
Semax has been found to directly enhance the dopamine release induced by dextroamphetamine in rodents: 20 pmol/ml extracellular DA vs 36-38 pmol/ml with Semax added.
Semax was also found to enhance dextroampethamine increased locomotor activity when compared to dextroampetamine alone (182% vs 261%).
Interestingly Semax alone did not alter locomotor or extracellular DA levels, suggesting a potentiation effect of the dopaminergic system rather than Semax being a direct stimulant
Dosage Guide
For nootropic purposes, a dose 0.25-1mg per day would seem suitable. A single dose is sufficient for the entire day and possibly beyond. Intranasal or Sub-Q administration are the only accepted ways of administering Semax. Do not consume by mouth or sublingually as Semax will be rendered inactive.
Lyophilised Semax will require reconstitution with sterile water before being suitable for injection or intranasal administration.
Synonyms: ACTH (4-7), Pro-Gly-Pro-;ACTH (4-7), Pro-Gly-Pro trifluoroacetate salt;L-Methionyl-L-a-glutamyl-L-histidyl-L-phenylalanyl-L-prolylglycyl-L-proline trifluoroacetate salt;Met-Glu-His-Phe-Pro-Gly-Pro;Semax
CAS: 80714-61-0
MF: C37H51N9O10S
MW: 813.929
Semax review
Semax is a heptapeptide developed by the Institute of Molecular Genetics, Russian Academy Of Science (IMG RAS)[1]. Semax was likely first developed in the 1980’s to early 1990’s and received authorization for marketing in 1994.[1]. In Russia, Semax is used to treat stroke, brain damage following ischemia, optic nerve disease and as a treatment for various cognitive disorders[2]. Additionally Semax has been shown in one human study to directly enhance cognitive function and favorably alter EEG bands
Benefits of Semax
Cognitive Enhancement
A 2 day study of Russian power plant workers tested the efficacy of Semax with a number memorization task.[4] In total the test lasted around 15 minutes and one was performed at the beginning and end of the workers’ shifts on days 1 and 2 respectively.
A dose of 1mg was given intranasally on day one around 1 hour prior to testing and on day two shortly after the morning’s tests. A placebo group was also requested to perform the same task
Semax dramatically decreased the number of incorrect responses on days one and two while the placebo group’s error rate actually increased (see above). Semax also attenuated a decrease in correct performance scores compared to placebo.
Mood
Animal studies reveal Semax is a potential mood enhancer and anxiety reducing compound. A study of in rats revealed Semax to be capable of attenuating CCK-4 induced stress and depression, while not affecting rats administered placebo.
Migraines
A study conducted in 1995 sought to test the analgesic activity of Semax and if it could be suitable for headache and migrane relief. The study featured 3 groups of patients; group 1 was 12 individuals suffering from migraines, group 2 included 16 patients suffering with trigeminal neuralgia while group 3 included 9 patients suffering with dental plexalgia
Potentiation Of Stimulants
Semax has been found to directly enhance the dopamine release induced by dextroamphetamine in rodents: 20 pmol/ml extracellular DA vs 36-38 pmol/ml with Semax added.
Semax was also found to enhance dextroampethamine increased locomotor activity when compared to dextroampetamine alone (182% vs 261%).
Interestingly Semax alone did not alter locomotor or extracellular DA levels, suggesting a potentiation effect of the dopaminergic system rather than Semax being a direct stimulant
Dosage Guide
For nootropic purposes, a dose 0.25-1mg per day would seem suitable. A single dose is sufficient for the entire day and possibly beyond. Intranasal or Sub-Q administration are the only accepted ways of administering Semax. Do not consume by mouth or sublingually as Semax will be rendered inactive.
Lyophilised Semax will require reconstitution with sterile water before being suitable for injection or intranasal administration.
Links:
Copyright © Wuhan Nutra Biotechnology Co., Ltd. All right reserved
