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Selank
Product Description:
Selank Peptide L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-L-Proline
Selank is not orally bio-available, as it’s a peptide which would be hydrolyzed and broken into it’s constituent amino acids in the gut. As such, the two methods of administration are intranasal and subcutaneous injection. If you purchase lyophilised / freeze dried selank powder. it’s generally stable for 3 months, though we’d advise refrigeration where possible.
Lyophilised selank will require reconstitution with bacteriostatic water before being suitable for injection or intranasal administration.
Selank’s Method of Action
Immunomodulatory
From a purely pharmacological standpoint, selank mimics a lot of the effects of tuftsin which is the endogenous peptide it is based upon. These effects include the balance of T helper cells and the modulation of the expression of Interleukin-6.
Additionally, there is evidence that suggests selank may modulate the expression of brain-derived neurotropic factor (BDNF)
Serotonin, Noradrenaline and Dopamine Modulation
Selank’s mechanism of action is suspected to be related to the increase of serotonin. Serotonin influence’s appetite, supports a positive mood, and regulates the sleep and wake cycle. It is also well established that a serotonin deficient state can lead to depression, difficulty sleeping, and lack of an appetite.
A study on mice to unveil the effects of selank on neurotransmitter monomines and their metabolites showed significant differences in the content of dopamine, serotonin, norepinephrine, and in the levels of their hypothalamus, hippocampus, and frontal cortex . Further research supports selank’s serotonin raising ability .
Selank and tuftsin were also shown to support serotonin levels despite rats being pre-treated with the serotonin synthesis inhibitor p-chlorophenylalanine. Serotonin metabolism was enhanced within 30 minutes of selank administration, however tuftsin was unable to raise 5-HT levels. .
Rodents exposed to 6-hydroxydopamine, a neurotoxin which damages the catecholaminergic system, had cognitive processes restored with selank .
Selank Benefits
Antidepressive Effects (Animal Study)
A study of mice genetically bred to suffer with depression demonstrated selank’s ability to fight adhedonia and restore pleasure seeking behaviors. Administration of selank increased sucrose self administration and reduced immobility during a forced swim test .
Anxiolytic / Anxiety Reducing
Selank as a Nootropic / Cognitive Enhancer
Dosage Guide
Generally 250-500mcg taken 1-2 times per day
Selank is not orally bio-available, as it’s a peptide which would be hydrolyzed and broken into it’s constituent amino acids in the gut. As such, the two methods of administration are intranasal and subcutaneous injection. If you purchase lyophilised / freeze dried selank powder. it’s generally stable for 3 months, though we’d advise refrigeration where possible.
Lyophilised selank will require reconstitution with bacteriostatic water before being suitable for injection or intranasal administration.
Selank’s Method of Action
Immunomodulatory
From a purely pharmacological standpoint, selank mimics a lot of the effects of tuftsin which is the endogenous peptide it is based upon. These effects include the balance of T helper cells and the modulation of the expression of Interleukin-6.
Additionally, there is evidence that suggests selank may modulate the expression of brain-derived neurotropic factor (BDNF)
Serotonin, Noradrenaline and Dopamine Modulation
Selank’s mechanism of action is suspected to be related to the increase of serotonin. Serotonin influence’s appetite, supports a positive mood, and regulates the sleep and wake cycle. It is also well established that a serotonin deficient state can lead to depression, difficulty sleeping, and lack of an appetite.
A study on mice to unveil the effects of selank on neurotransmitter monomines and their metabolites showed significant differences in the content of dopamine, serotonin, norepinephrine, and in the levels of their hypothalamus, hippocampus, and frontal cortex . Further research supports selank’s serotonin raising ability .
Selank and tuftsin were also shown to support serotonin levels despite rats being pre-treated with the serotonin synthesis inhibitor p-chlorophenylalanine. Serotonin metabolism was enhanced within 30 minutes of selank administration, however tuftsin was unable to raise 5-HT levels. .
Rodents exposed to 6-hydroxydopamine, a neurotoxin which damages the catecholaminergic system, had cognitive processes restored with selank .
Selank Benefits
Antidepressive Effects (Animal Study)
A study of mice genetically bred to suffer with depression demonstrated selank’s ability to fight adhedonia and restore pleasure seeking behaviors. Administration of selank increased sucrose self administration and reduced immobility during a forced swim test .
Anxiolytic / Anxiety Reducing
Selank as a Nootropic / Cognitive Enhancer
Dosage Guide
Generally 250-500mcg taken 1-2 times per day
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