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Wuhan Nutra Biotechnology Co., Ltd.ISRIB ,Cosmetic Peptide, Tideglusib ,Way316606,Nootropics |
    
   
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E-mail: catherine@nutrabiotechchem.com
Synonyms: COLURACETAM;N-(2,3-Dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide;1-Pyrrolidineacetamide,2-oxo-N-(5,6,7,8-tetrahydro-2,3-dimethylfuro[2,3-b]quinolin-4-yl)-;Coluracetam, MKC-231;1-[N-(2,3-DiMethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)carbaMoylMethyl]pyrrolidin-2-one;BCI-540;Coluracetam, >=99%
CAS: 135463-81-9
MF: C19H23N3O3
MW: 341.4
MECHANISM OF ACTION
As with many of the racetam compounds, Coluracetam elevates the body’s choline uptake, while also increasing the uptake in damaged neurons. The compound targets and interacts with the high affinity choline uptake (HACU) process, which is the mechanism for absorbing choline into neurons. The uptake increase happens during the Acetylcholine synthesis process.
Because Coluracetam improves the preservation of choline during this process, the result is that a larger amount of choline is converted into Acetylcholine. The beneficial yield from the process incudes an increased amount of attention and alertness, along with improvements to memory.
Research shows that Coluracetam also improves α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA) potentiation, a receptor for glutamate that aids in synaptic transmission in the central nervous system process that boosts alertness and cognitive functions.
COLURACETAM USES (MEDICAL RESEARCH)
Studies show that Coluracetam shows the greatest potential in treating both general anxiety and clinical depression. Other studies show that the compound also shows promise in the treatment of optic nerve and retinal injury.
COLURACETAM BENEFITS
BrainCells Inc. started testing the effects of Coluracetam on rats after acquiring the patent from Mitsubishi Tanabe. Research results indicate there were marked improvement in the rodent’s eyesight, anxiety processing and cognitive functioning after testing with the compound.
EYESIGHT
Research conducted on Coluracetam indicated that it is beneficial in the treatment of retinal and optic nerve injuries. It is also associated with other optic benefits such as visual recognition and vividness and improved color vision.
DEPRESSION AND ANXIETY
Researchers reported that a dosage of 240 mg of the compound split into three doses of 80 mg daily was beneficial in treating major clinical depression co-morbid with generalized anxiety disorder.
MEMORY AND LEARNING
A study using Coluracetam showed improvement to memory in rats who were given a neuron-specific neurotoxin. The rats were later able to maneuver through the standardized Morris Water Maze up to 72 hours after the last dosage of the compound.
COLURACETAM SAFETY, TOLERANCE & DRUG INTERACTIONS
Currently there have not been any negative side effects or toxicity reported with Coluracetam use. At the end of clinical trials using a daily dose of 240 mg per day (given three equal administrations) no side effects were reported. This dosage amount was the highest suggested dosage of the compound used in any of the trials to date.
